Marty Makary has resigned as Commissioner of the US Food and Drug Administration following a high-stakes policy clash with the Trump administration over the approval of flavored e-cigarettes, according to The New York Times. Dr. Marty Makary, Food and Drug Administration (FDA) commissioner, attends an event on health care affordability in the Oval Office at the White House, April 23, 2026, in Washington. (AP) His departure on Tuesday comes after weeks of internal pressure and growing tension inside the agency, with officials reportedly anticipating a possible firing or forced exit before Makary ultimately stepped down. Flavored vape approval dispute The key trigger behind Makary’s resignation was a disagreement over the administration’s decision to authorize fruit-flavored vaping products, a move he privately opposed. People familiar with the matter said, as per NYT, that Makary believed flavored e-cigarettes posed a significant risk to young people due to their appeal and addictive nicotine content. He reportedly told close associates he could not support the decision in good conscience and would not approve a policy he fundamentally disagreed with. …