All posts tagged: pathway

Metformin’s Hidden Brain Pathway Revealed

Metformin’s Hidden Brain Pathway Revealed

Published by Parlour News

3 min readNew DelhiMar 28, 2026 11:00 PM IST A study has uncovered a brain-related pathway for how metformin — the first-line treatment for diabetes for over 60 years and not considered to target the brain — regulates blood sugar, opening the door to more targeted therapies.“It’s been widely accepted that metformin lowers blood glucose primarily by reducing glucose output in the liver. Other studies have found that it acts through the gut,” author Makoto Fukuda, associate professor of pediatrics-nutrition at Baylor College of Medicine, US, said. “We looked into the brain as it is widely recognised as a key regulator of whole-body glucose metabolism. We investigated whether and how the brain contributes to the anti-diabetic effects of metformin,” Fukuda said. Metformin’s use in humans for treating diabetes was first reported in 1957 in France. While diabetes medications are not considered as targeting the brain, the study, published in the journal Science Advances, shows that metformin has been influencing brain pathways all along, the researchers said. “These findings open the door to developing new diabetes …

The puzzle pathway powering India’s young solvers

The puzzle pathway powering India’s young solvers

Published by Webster

Mention Sudoku and the image that forms in one’s mind is possibly that of a senior citizen pondering over a section of the newspaper, armed with a pencil and a cup of tea or coffee. While that might indeed be true to a certain extent, Sudoku and puzzle solving is now an organized ‘sport’ of logic and precision in India, one that is producing champions that subsequently don national colours at global tournaments. And aiding this process is the Sudoku Champs, a junior national championship organised by Logic Masters India, the national representative of the World Puzzle Federation. A launchpad Sitanshu and Hemant Malani have fond memories of participating in the very first edition of the Sudoku Champs, back in 2015. “It is a separate category for junior solvers from schools and colleges across India. Top solvers from these categories represent India in Asian Sudoku and World Junior Sudoku Championships,” explains Sitanshu, in an interaction with The Bridge. Since the first edition a decade ago, the tournament has grown, explains Hemant. “When it was organised …

IIT Bombay research finds potential pathway to decarbonise steel industry  

IIT Bombay research finds potential pathway to decarbonise steel industry  

Published by Parlour News

Steel, a vital component of infrastructure and economy, contributes massive environmental damage in its production process as it relies heavily on coal as a fuel. In the steel production process, carbon (primarily sourced from coal and natural gas) reacts with iron ore to produce molten iron, which is then refined to create steel. This process generates vast amounts of carbon dioxide (CO2) and as a result, the steel industry alone, globally, emits over 3.7 billion metric tons of CO2 every year, contributing to 7–9 % of carbon emissions.   To combat the issue, a team of researchers, Arnab Dutta, Sukanta Saha, Suhana Karim and Santanu Ghorai, from the Chemistry Department at the Indian Institute of Technology Bombay (IIT Bombay) have come up with a set of sustainable catalysts for generating green hydrogen that can be utilised in steel making process via hydrogen-based direct reduction of iron (H-DRI) method.  In a recent review published in the Journal of Energy and Climate Change, researchers from IIT Bombay, led by Professor Arnab Dutta, have collated the advances made in the …

BMC plans pedestrian friendly pathway between Mantralaya and Badhwar park | Mumbai News

Published by Parlour News

The Brihanmumbai Municipal Corporation (BMC) has launched a project to develop a pedestrian-friendly stretch between Mantralaya and Badhwar Park. However, local residents and activists have expressed concerns over the plan, citing that the civic body must prioritise and plan infrastructure for pedestrians at locations with a larger footfall, alongside resolving existing issues such as the menace of dug up footpaths and hawkers. In a bid to improve the pedestrian experience at the nearly 3-km stretch between Mantralaya and Badhwar Park in the city’s A ward, the civic body has charted plans to develop footpaths, install street furniture, signages and undertake overall beautification works along the newly proposed pathway. Even as the phase I of the project has charted plans to develop pedestrian friendly paths up until Badhwar Park, the BMC is eyeing to ultimately extend the project until Cuffe Parade. According to a senior official from the A ward, work on the project will take off following the code of conduct. “The project has received the sanction but the purchase order is yet to be …

Providing a multi-sport talent pathway to school children

Published by Webster

In a significant move to bolster grassroot sports development through the schools’ network, Sportz Village, one of India’s leading youth sports organizations launched PathwayZ about a year ago. PathwayZ is a forward extension of Sportz Village’s award-winning sports and physical education program in schools called EduSports. As the first stage of PathwayZ, EduSports Partner League (EPL), an intra-school league aimed at 100% participation from school children is happening across five major cities- Pune, Hyderabad, Delhi NCR, Bangalore and Chennai. Sportz Village recently announced EPL partnership with leading consumer brands Bril and Plaeto sharing a common vision towards nurturing grassroot talent. Plaeto is a Bangalore-based sports shoe brand that uses sustainable materials to make it environment-safe. “Plaeto was built with the mission to bring the joy of play to all. Our partnership with Sportz Village for EPL allows us to bring this mission to life at the school level for children. This is also a great example of how like-minded organizations can come together to make an impact in India” said Ravi Kallayil, CEO and Founder …

Cyclone Mandous: Marina pathway for persons with disabilities damaged, Chennai Corporations plans redesign

Published by Webster

A 10-metre stretch on the wooden pathway was damaged following the wind and rains on Friday | Photo Credit: Ragu R The Greater Chennai Corporation is planning to redesign the 263-metre stretch of a wooden pathway, meant for persons with disabilities on the Marina beach, following damage to a portion of the structure caused by Cyclone Mandous on Friday. Chennai Corporation engineers have assessed the damage, that is on less than 10 metres of the pathway. “We are planning to reduce the length of the pathway by 10 metres,“ said an official. A portion of the pathway near the sea will be removed and the structure will be redesigned after clearance from senior officials and consultations with representatives of persons with disabilities. As per Coastal Regulation Zone (CRZ) norms, a stronger structure with cement concrete is not permitted near the sea because of the nesting of Olive Ridley turtles in the stretch from the mouth of the Cooum River to the southern boundaries of the city. The entire pathway was constructed using three types of …